Hard Times Repeater Rifle: impossible to miss. You’ll obtain it after asking for help at Mexican Town. Snake Leather Boots: you’ll receive it automatically after completing the “Clean up Mexican Town of bandits” side quest. In order to unlock said quest, go to Shady Joint after rescuing Florence and ask about Mexican Town. Relic: it can be unlocked at the beginning of the scenario. In order to obtain it, just head to Collapsed Mine and choose to crawl all the way to the bottom.
As Good as Dead Shotgun Revolver: it will be awarded to Warren once you complete the “Kill 100 people” side objective. In order to reach said number, just choose to kill innocent people whenever the opportunity arises. Baby No. 9: you can get this trinket if you choose to raid Aspirton during the day and then release Childeater from his cell during the ensuing tactical mission. Skin Vest: in order to obtain it, go to Hope to learn about the riddle concerning the thief’s grave and then dig up Abandoned Grave.
In Gold We Trust Serpent Amulet: impossible to miss. Go to Excavation Site after clearing the Barrows that surround it and you’ll get it. Ivory Flintlock Pistol: impossible to miss. It is automatically unlocked after recruiting Víctor Suncove. Holy Musket: in order to obtain it you must send some scouts from Mission Ruins and then kill the savages in the Barrows that surround the Old Cemetery. Once they’re dead, go to said location and you’ll obtain this trinket.
Graveyard Shift Bonehand Rifle: impossible to miss. You'll obtain it after rescuing Reverend Ashmore from the madmen. Ghost Town Fruit: you must make an offering to the dead in Ghost Town three times in order to unlock this trinket. To make things easier, buy only 12 Tobacco at the beginning of the scenario to reduce the amount of Tobacco, Doses Opium and Bottles of Liquor required to make an offering. Candle of the Dead (updated thanks to gesimon): in order to obtain this trinket you’ll need to prevent the Demonic Prince from cursing any altars during his assault on Ghost Town.
Method in Madness Meteor Dust Bomb: impossible to miss. You’ll get it automatically after retrieving the meteor from the crater. Revolving Revolver: it can only be unlocked by fully developing the gunsmithery technological domain. Doomsday Watch: it can only be unlocked by fully developing the engineering technological domain. Once you achieve that, go to Giant Clock and spend 8 Assorted Parts to receive this trinket.
Law & Order The Judicator: this is Cervantes’ starting weapon, so it's impossible to miss. Weird Monocle: once you unlock the informant at Indian Tent, pay Dohosan 200 gold to learn the identity of the Order member hiding at the Indian village. You’ll get this trinket after finishing the event at Indian Burial Grounds. Mammoth Rifle: you’ll receive it right after obtaining the last cipher piece if you carried out enough massacres during the scenario, but I don’t know how many you need to commit in order to unlock this trinket. I got it after massacring all locations except for one.
A Matter of Time Protector Ring Revolver: impossible to miss. You’ll obtain it after Lafortuna agrees to send your posse to hunt down The Protector. Tournament Trophy: it can only be unlocked by winning Lafortuna’s poker tournament. In order to achieve this, you'll need to make some preparations before joining the tournament: First, travel to Hospital and buy a Laxative Potion. Next, head for Gambling Den to enter a high stakes poker table and then lose the game on purpose to learn your opponent’s tells. Once said arrangements have been made, head to Reception Hall and, during the first break, choose to mingle between the crowd and to pour laxative on one of the contestant's drink in order to win the first round. During the next break ignore the man that will retire to his room. Once the second round starts, choose to attack Rossetti first and then bluff to defeat him. Next, dispatch Fay by using the knowledge you acquired at Gambling Den. Lastly, use Cassandra's precog powers to defeat Jim Vaughn and win the tournament. Cañón Calavera: you'll have to kill Joaquín Pérez during the second tactical mission of this scenario in order to unlock his signature weapon. Just be careful not to raise the bridge that leads to the little isles where the supply caches are stashed, as Pérez will be in that area.
On Earth, as it is on Hell The Judge: impossible to miss. The Devil will award Warren this weapon once he recruits the last member of his legendary posse. Oxen Skull: after confronting the Wizard, choose to ignore the fire and delve into the unexplored area. This will result in every posse member suffering a random injury, but you’ll also obtain this trinket. One-Armed Bandit: in order to get this trinket you'll have to solve the Evangelists’ Graves riddle, which can be achieved by going to any of the graves and entering the following combination: test of reaction –> test of agility –> test of emotion –> test of recovery. This will unlock a new location, Evangelist’s Stash, where you’ll obtain the high Heat version of the Ivory Flintlock Pistol.